Description

Functions

• Physiological Roles: Neu5Ac is a terminal sugar in cell surface glycans and glycoconjugates, essential for cell-cell interactions, immune responses, and pathogen recognition. It is also involved in the development and function of the nervous system.
• Antiviral Applications: Neu5Ac is a key component in the synthesis of antiviral agents like zanamivir and oseltamivir, which inhibit viral neuraminidase enzymes, preventing the release of new viral particles from infected cells.
• Therapeutic Potential: Neu5Ac extended-release formulations have been explored for treating GNE myopathy, a neuromuscular disease. It helps improve muscle strength and function by providing the necessary sialic acid for glycosylation processes.
• Nutritional Benefits: Neu5Ac is a key component of human milk oligosaccharides (HMOs) and is added to infant formula to support immune development and cognitive health in infants.

Applications

• Pharmaceutical Industry: Development of antiviral drugs and potential therapeutic agents for autoimmune diseases and cancer. Neu5Ac is also used in the treatment of GNE myopathy.
• Medical Diagnostics: Serves as a biomarker for diseases like cancer and viral infections. It is used in diagnostic assays to detect the presence of pathogens or abnormal cells.
• Biotechnology: Used in the modification of proteins to enhance stability and bioactivity. Neu5Ac is also used in the development of vaccines and other biologics.
• Food Industry: Added to infant formula and functional foods to support immune health and cognitive development. It is also used in dietary supplements for its health benefits.
• Cosmetic Industry: Used in skincare products for its moisturizing and anti-aging properties. Neu5Ac helps improve skin hydration and elasticity.