S-Acetyl-L-Glutathione

S-Acetyl-L-Glutathione

S-Acetyl-L-Glutathione is a bioavailable, stabilized form of glutathione (GSH), the body’s master antioxidant. Unlike conventional reduced glutathione, which has poor absorption and rapid degradation in the digestive tract, S-Acetyl-L-Glutathione features an acetyl group attached to its cysteine residue, protecting it from enzymatic breakdown and allowing efficient cellular uptake. Once absorbed, it is deacetylated intracellularly, releasing active glutathione to replenish endogenous pools.

This modified form offers >90% oral bioavailability, making it far superior to traditional glutathione supplements. It is pH-stable, resistant to oxidation, and capable of crossing the blood-brain barrier, enabling systemic antioxidant and detoxification effects. Clinically, it is used to restore glutathione levels in aging, chronic illness, and toxin-exposed individuals.

ENQUIRY!

Description

Product Name S-Acetyl-L-Glutathione
Appearance White Powder
Specification 99%
Test Method HPLC UV
CAS 3054-47-5
MF C12H19N3O7S
Certificate ISO/cGMP/KOSHER/HALAL/USDA ORGANIC

Functions

  • Potent Antioxidant Defense: Directly scavenges free radicals (ROS/RNS) and regenerates vitamins C & E, amplifying the antioxidant network. Protects mitochondria from oxidative damage, slowing cellular aging and improving energy metabolism.
  • Liver Detoxification & Heavy Metal Chelation: Conjugates with xenobiotics, drugs, and heavy metals (e.g., mercury, lead) for biliary excretion. Supports Phase II liver detox enzymes (glutathione S-transferases), crucial for toxin clearance.
  • Skin Brightening & Anti-Pigmentation: Inhibits tyrosinase by interrupting melanin synthesis pathways, leading to a brighter, more even complexion.
  • Reduces melasma, age spots, and post-inflammatory hyperpigmentation (PIH).
  • Immune System Modulation: Enhances lymphocyte proliferation and NK cell activity, improving resistance to infections. Reduces chronic inflammation by lowering pro-inflammatory cytokines (IL-6, TNF-α).
  • Neuroprotection & Cognitive Support: Crosses the blood-brain barrier to combat neuroinflammation and oxidative stress in neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s). May improve memory, focus, and mood by regulating glutamate and dopamine levels.
  • Exercise Performance & Recovery: Reduces exercise-induced oxidative stress, delaying muscle fatigue. Accelerates post-workout recovery by lowering lactate buildup and inflammation.

Applications

  • Clinical & Therapeutic Use: IV glutathione therapy for liver diseases (NAFLD, hepatitis), Parkinson’s, and chemotherapy support. Oral supplements for chronic fatigue, detox protocols, and longevity regimens.
  • Cosmeceuticals: Whitening serums & brightening creams-Used at 2-5% concentrations for pigmentation correction. Anti-aging formulations-Combats photoaging and improves skin elasticity.
  • Sports Nutrition: Pre- and post-workout supplements-Enhances endurance and reduces muscle damage.
  • Neurological Health: Nootropic stacks-Combined with NAC and alpha-lipoic acid for cognitive enhancement.
  • Anti-Pollution Skincare: Urban defense serums-Protects against PM2.5 and heavy metal toxicity.