Description

Functions​

Nitric Oxide Production and Cardiovascular Health: L-Citrulline is converted to L-arginine in the body, a precursor for nitric oxide (NO) synthesis. NO is essential for vasodilation, widening blood vessels and improving blood flow. Studies have demonstrated that L-Citrulline supplementation can lower blood pressure and enhance blood vessel elasticity. In individuals with mild hypertension, regular intake of L-Citrulline has been associated with reduced systolic and diastolic blood pressure readings, decreasing the risk of cardiovascular diseases like heart attacks and strokes.​

Muscle Recovery and Exercise Performance: During exercise, L-Citrulline helps reduce muscle fatigue. By increasing NO production, it improves oxygen delivery to muscles, allowing them to function more efficiently. Research on athletes shows that L-Citrulline supplementation can increase exercise endurance, delay the onset of fatigue, and speed up post-workout recovery. For example, in endurance runners, L-Citrulline intake has been linked to improved time to exhaustion and reduced muscle soreness after intense training sessions.​

Liver Detoxification: As part of the urea cycle, L-Citrulline aids the liver in removing ammonia, a toxic byproduct of protein metabolism. By combining with ammonia to form L-arginine and urea (which is excreted), it supports liver function and helps maintain a healthy nitrogen balance. This is particularly beneficial for individuals with liver diseases or those on high-protein diets, preventing ammonia build-up that could lead to serious health issues.​

Applications​

Sports Nutrition: L-Citrulline is a staple in sports nutrition products. Pre-workout supplements often contain L-Citrulline to enhance blood flow to muscles, providing more oxygen and nutrients, and increasing energy levels during exercise. Recovery formulas utilize its muscle repair properties, helping athletes bounce back faster after strenuous workouts. It’s also found in endurance drinks, supporting prolonged physical activity.​

Cardiovascular Health Supplements: In the health supplement market, L-Citrulline is used in products aimed at improving cardiovascular health. These supplements target individuals at risk of heart disease, high blood pressure, or poor circulation. They often combine L-Citrulline with other heart-healthy ingredients like omega-3 fatty acids, CoQ10, and magnesium for comprehensive support.​

Pharmaceutical Research: L-Citrulline serves as a valuable intermediate in pharmaceutical research. Scientists explore its use in developing drugs related to nitric oxide pathways, potentially for treating conditions such as erectile dysfunction, peripheral artery disease, and certain types of hypertension. Its role in enhancing blood flow makes it a promising candidate for novel therapeutic interventions.